An improved 11 α-hydroxylation of progesterone by Aspergillus ochraceus TS

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Transformation of steroids by spores of microorganisms. I. Hydroxylation of progesterone by conidia of Aspergillus ochraceus.

Conidia of Aspergillus ochraceus convert progesterone into 11alpha-hydroxyprogesterone and 6beta, 11alpha-dihydroxyprogesterone. The conversion ability does not depend on the sporulation medium. Transformation depends on the strain and on the conidia concentration. Adaptation has never been observed. Age and storage of conidia, pH, aeration-agitation, nitrogen source, metal ions, chelating agen...

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Hydroxylation of progesterone and 11-desoxy-17-hydroxycorticosterone by Aspergillus and Penicillium.

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Ochratoxin production by the Aspergillus ochraceus group and Aspergillus alliaceus.

Ochratoxin A is a toxic and carcinogenic fungal secondary metabolite; its presence in foods is increasingly regulated. Various fungi are known to produce ochratoxins, but it is not known which species produce ochratoxins consistently and which species cause ochratoxin contamination of various crops. We isolated fungi in the Aspergillus ochraceus group (section Circumdati) and Aspergillus alliac...

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Aspergillus nodules in chronic granulomatous disease attributable to Aspergillus ochraceus

Aspergillus ochraceus is a rare pulmonary pathogen. A 39 year old male with COPD and chronic granulomatous disease presented with severe breathlessness and recurrent infections. CT scan demonstrated multiple pulmonary nodules diagnosed as chronic pulmonary aspergillosis. The patient's sputum grew Aspergillus ochraceus thrice over 6 months, alongside positive Aspergillus IgG and serum galactoman...

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Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger

The monoterpenoid 1,8-cineole is obtained from the leaves of Eucalyptus globulus and it has important biological activities. It is a cheap natural substrate because it is a by-product of the Eucalyptus cultivation for wood and pulp production. In this study, it was evaluated the potential of three filamentous fungi in the biotransformation of 1,8-cineole. The study was divided in two steps: fir...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1978

ISSN: 0306-3283

DOI: 10.1042/bj1760593